Chávez Munguia Bibiana PhD

Profesor Bibiana Chávez Munguía PhD

Current position: Profesor
Present adscription: Department of Infectomics and Molecular Pathogenesis.Cinvestav-IPN, Mexico.
Address: Av. IPN, No. 2508, San Pedro Zacatenco. CP. 07360
Phone number: + 52 (55) 57-47-3800 ext 5656. Fax: (525) 747 7107
E-mail:bchavez@cinvestav.mx

Academic profile:

Undergraduate studies: Biologist: Universidad Nacional Autónoma de México. México City, México. 1969.
Mr. Sc.: Cell Biology.Universidad Nacional Autónoma de México. México City, México. 1975.
Ph. D. Experimental Pathology. Centro de Investigación y de Estudios Avanzados del IPN. Mexico City, México. 1995.

Parasites that affect to humans as Giardia lamblia and Entamoeba histolytica present two morphologically different phases in their life cycle. One of them is the trophozoite that feeds and multiply into the host, the other is the cyst capable to resist external environmental conditions. By this capacity, the cyst, is the form of the parasite that reproduce the infection in new hosts. In addition, free living amebas as Acanthamoeba castellanii and Naegleria fowleri are capable of produce severe infections in humans also present these two phases.

Adverse environmental conditions induce the encystment, in this process a thick external cyst wall is produced and the microorganisms adopt structural characteristics required to remain alive. On the contrary, excystation occurs when environmental conditions are propitious for the trophozoite reestablishment.

Using electron microscopy methods we study the trophozoite-cyst and cyst-trophozoite differentiation processes. Besides, using in vitro models, we study different aspects of the cell biology and the cytopathic effect produced by these microorganisms.
 

  1. Chávez-Munguía B, Cristobal-Ramos A R, González-Robles A, Tsutsumi V y Martínez-Palomo A (2003). Ultrastructural study of Entamoeba invadens encystation and excystation. Journal of Submicroscopic Cytology and Pathology 35 (3): 235-243.

  2. Chávez-Munguía B,  Cedillo-Rivera R y Martínez-Palomo A (2004). Giardia lamblia: Ultrastructure of cyst wall membranes. J. Eukaryotic Microbiology 51 (2), 219-225.

  3. Chávez-Munguía B, Hernández-Ramírez V, Ángel A, Ríos A, Talamás-Rohana P, González-Robles A, González-Lázaro M, y Martínez-Palomo A. (2004). Entamoeba histolytica: Ultrastructure of trophozoites recovered from experimental liver lesions. Journal of Experimental Parasitology 107 (1-2): 39-46.

  4. Chávez-Munguía B, Omaña-Molina M, González-Lázaro M, González-Robles A, Bonilla P y Martínez-Palomo A (2005). Ultrastructural study of encystation and excystation in Acanthamoeba castellanii. J. Eukaryotic Microbiology 52 (2): 153-158.

  5. Chávez-Munguía B, Tsutsumi V y Martínez-Palomo A. (2006). Entamoeba histolytica: ultrastructure of the chromosomes and the mitotic spindle. Experimental Parasitology 114: 235-239.

  6. Chávez-Munguía B, Omaña-Molina M, González-Lázaro M, González-Robles A, Cedillo-Rivera R, Bonilla P y Martínez-Palomo A. (2007). Ultarstructure of cyst differentiation in parasitic protozooa (Review). Parasitology Research 100 (6) 1169-1175.

  7. Chávez-Munguía B, Talamás-Rohana P, Ríos A, González-Lázaro M, Martínez-Palomo A, (2008). Entamoeba histolytica: Fibrilar aggregates in dividing trophozoites. Experimental Parasitology 118 (2) 280-284.

  8. Chávez-Munguía B, Omaña-Molina M, Castañón G, Bonilla P, González-Lázaro M, Hernández-Martínez D, Salazar-Villatoro L, Esparza-García A, Martínez-Palomo A, Ortega-Pierres G (2009). Naegleria sp.: ultrastructure of the encystation and excystation processes. Journal of Eukaryotic Microbiology 56(1) 66-72.

  9. Chávez-Munguía B, Segovia-Gamboa  NC, Salazar-Villatoro L, Omaña-Molina M, Espinosa-Cantellano M, Martínez-Palomo A (2011). Naegleria fowleri: Enolase is expressed during cyst differentiation. Journal of Eukaryotic Microbiology 58 (5) 463-468.

  10. Chávez-Munguía B and Martínez-Palomo A (2011). High Resolution Electron Microscopical Study of entamoebae cyst walls. Journal of Eukaryotic Microbiology 58 (6) 480-486.

  11. Chávez-Munguía B, Castañón G, Hernández-Ramírez V, González-Lázaro M, Talamás-Rohana P, Martínez-Palomo A (2012). Entamoeba histolytica electrondense granules secretion in vitro and in vivo: ultrastructural study. Microscopy Research and Technique 7 75 (2), 189-196.

  12. Chávez-Munguía B., Talamás-Rohana P, Castañón Gutiérrez G, Salazar-Villatoro L, Hernández-Ramírez V,  Martínez-Palomo A (2012). Differences in cap formation between invasive Entamoeba histolytica and non-invasive Entamoeba dispar. Parasitology Research 111:215-221.

  13. Chávez-Munguía B, Salazar-Villatoro L, Lagunes-Guillén A, Omaña-Molina M, Espinosa-Cantellano M, Martínez-Palomo A (2013). Acanthamoeba castellani cyst: new ultrastructural findings. Parasitology Research (in press)