Ludert León Juan Ernesto PhD

Dr. Juan E. Ludert León

Current position: Professor,  Academic Coordinator
Present adscription: Department of Infectomics and Molecular Pathogenesis. Cinvestav, IPN, Mexico.
Address: Av. IPN, No. 2508, San Pedro Zacatenco. CP. 07360
Phone number: + 52 55 57473800, ext. 5635 Fax: + 52 55 57473377

Academic profile

Undergraduate studies. Bachelor of Science, Florida State University. Tallahassee, Florida, USA. 1981.
M. Sc.: Microbiology, Venezuelan Institute for Scientific Research (IVIC). Caracas, Venezuela. 1986.
Ph.D.: Microbiology, Venezuelan Institute for Scientific Research (IVIC). Caracas, Venezuela. 1993.
Postdoctoral fellowship: Stanford University School of Medicine. Palo Alto, California, USA. 1995.


Our research interest is oriented toward the identification of host resistance and susceptibility factors to dengue virus infection as well as to the identification of host markers of increased progression risk from dengue fever to dengue hemorrhagic fever.

It is also of our interest to understand the pathogenesis of the severe forms of the disease, especially the mechanisms leading to plasma leakage, a hallmark of patients affected with severe dengue. It is our hope that such studies will contribute information useful to the development of specific dengue treatments.

  1. Ludert, J.E., Mosso, C., Ceballos-Olvera, I., del Angel, R.M. 2008. Use of a commercial enzyme immunoassay to monitor dengue virus replication in cultured cells. Virology Journal 5: e 51.

  2. Zambrano, J.L., Díaz Y., Peña, F., Vizzi, E., Ruiz, M.C., Michelangeli, F., Liprandi, F., Ludert, J.E. 2008. Silencing of rotavirus NSP4 or VP7 expression reduce alterations in Ca2+ homeostasis induced by infection in cultured cells. Journal of Virology 82: 5815-5824.

  3. Mosso, C., Galván-Mendoza I.J., Ludert J.E. del Angel, R.M. 2008.Endocytic pathway followed by dengue virus to infect the mosquito cell line C6/36 HT. Virology 378: 193-199.

  4. Agis-Juárez, R., Galvan I., Medina, F., Daikoku, T., R. Padmanaban, Ludert J.E., Del Angel R.M. 2009. The polypyrimidine-tract binding protein is relocated to the cytoplasm and is required during dengue virus replication in Vero cells. Journal of General Virology, 90: 2893-2901.

  5. Puerta-Guardo H., Mosso C., Medina F., Liprandi F., Ludert, J.E., Del Angel, R.M. 2010. The antibody dependent enhancement (ADE) of dengue virus infection in U937 cells requires cholesterol rich membrane microdomains. Journal of General Virology, 91: 394-403.

  6. Ceballos-Olvera I., Chávez-Salinas S., Medina F., Ludert J.E. del Angel, R.M. 2010. JNK Phosphorylation, induced during dengue virus infection, is important for viral infection and requires the presence of cholesterol. Virology, 396: 30-36.

  7. Nates S.V., Gatti, M.S.V., Ludert, J.E. 2011. The Picobirnavirus: an integrated view in its biology, epidemiology and pathogenic potential. (Review). Future Virology, 6(2): 223-235.

  8. De la Cruz Hernández S.I., González Mateos S., Flores Aguilar H, López Martinez I., Alpuche  Aranda C., Ludert J.E., Del Angel R.M. 2012. Evaluation of a novel commercial rapid test for dengue diagnosis based on specific IgA detection. Diagnostic Microbiology and Infectious Disease. 72:150-155.

  9. Puerta-Guardo H., Medina F., De la Cruz Hernandez S.I., Rosales V.H., Ludert, J.E., Del Angel, R.M. 2012. The 1-alpha, 25-Dyhidroxy-Vitamin D3 reduces dengue virus infection in human myelomonocyte (U937) and hepatic (Huh-7) cell lines and cytokine production in the infected monocytes. Antiviral Research, 94:57-61.

  10. De la Cruz-Hernández S.I., Flores-Aguilar H., González-Mateos S., López-Martínez I., Alpuche-Aranda C., Ludert J.E., del Angel R.M. 2013. Determination of Viremia and Concentration of Circulating NS1 Protein in Mexican Patients Infected with Dengue Virus. American Journal of Tropical Medicine and Hygiene, 88: 446-454.