Tsutsumi Víctor PhD

Dr. Víctor Tsutsumi Current Position: Professor
Present Adscription: Department of Infectomics and Molecular Pathogenesis.Cinvestav, IPN, Mexico. 
Address: Av. IPN, No. 2508, San Pedro Zacatenco. CP. 07360
Phone number: + 52 (55) 57-47-3896
Email: vtsutsu@cinvestav.mx

Academic profile

MD degree: Faculty of Medicine, National University of Mexico. 1967
Research Fellow: Department of Pathology, Queen´s University, Kingston, Ontario, Canada. 1968-1970.
Pathology Specialization: National Registry of Pathology. Secretary of Health. 1976
MSc degree: Department of Physiology, National School of Biological Sciences. National Polytechnic Institute. 1987
PhD degree: Department of Physiology, National School of Biological Sciences. National Polytechnic Institute. 1992.
Sabbatical: Kurume University School of Medicine. Division of Medicine. Center Innovative Cancer Research. Japan. 2008-2009.
National System of Researchers (SNI) National Council for Science and Technology, Mexico: Level III

Research topicsRepresentative Publications

The main interest in our laboratory has been focused to determine the mechanisms of damage of some parasitic infections that constitute important public health problem in Mexico. The amebiasis is an intestinal infectious disease produced by the protozoan parasite Entamoeba histolytica. One of the interests has been the study of humoral and cellular immune responses (natural and specific immunities) and the cell changes occurring during the host-parasite interaction in the intestine and the liver. Using in vivo animal models either susceptible or resistant to infection, we are presently analyzing the role of several lectins and other molecules (cytokines, nitric oxide, oxidative stress, etc.) during the evolution of the lesions produced by E. histolytica. Moreover, our studies on the innate and specific immune responses have been related with the induction of protection against the infection.

Another important research line has been related with Free Living Amebas, especially Naegleria fowleri and Acanthamoeba spp. These amebas produce diverse types of human diseases, including the Primary Amebic Meningoencephalitis, Granulomatous Encephalitis and Amebic Keratitis (damage in the cornea). In our laboratory we have established in vivo animal models to determine the pathogenesis of the Amebic Keratitis and the Primary Amebic Meningoencephalitis. Currently we are using different and new methodologies (molecular and cell biology) that facilitate our understanding on the mechanisms of tissue invasion and damage. Our interest has been also focused on the role of the innate and specific responses that are involved in these infections.

Regarding the chronic degenerative diseases, we are interested in the experimental liver cirrhosis and cancer. We are presently studying the role of inflammatory cells and reactive oxygen species (ROS) during the evolution of these important liver diseases. Using experimental animal model (rat) we are evaluating various anti-cirrhotic drugs that could be effective candidates for further treatment in humans.